Progesterone Oral

Progesterone Oral is micronized progesterone taken by mouth. It is typically prescribed to women with an intact uterus who use systemic estrogen as part of hormone replacement therapy.

Because it may cause drowsiness, it is often taken at bedtime. Your provider will determine whether it’s appropriate for you, as well as the dose and regimen.

Uterine Lining Protection

• When systemic estrogen stimulates the uterine lining, progesterone is prescribed alongside it as part of your overall treatment plan.

Micronized for Oral Use

• Micronized progesterone is processed into fine particles so it can be taken orally.

Personalized Regimen

• Your provider sets the dose and schedule based on your stage of menopause, bleeding pattern, and treatment goals. Regimens may be continuous or cyclic.

Women who still have a uterus generally need adequate progesterone or another progestogen alongside systemic estrogen. Women who have had a hysterectomy may be able to use estrogen without progesterone, depending on their history and your provider’s recommendation.

Micronized progesterone is commonly taken orally and may cause drowsiness, so bedtime dosing is often used when prescribed. Your provider will confirm the schedule that’s right for you.

Your provider reviews your personal and family history, blood pressure, bleeding pattern, symptom response, and any side effects after treatment begins and periodically thereafter. Routine hormone-level testing is not required for every woman using standard therapy, but may be ordered when clinically appropriate.

Any new or persistent vaginal bleeding after menopause requires prompt evaluation.

Common During Adjustment:

• Breast tenderness
• Bloating or fluid retention
• Spotting or irregular bleeding
• Headache or nausea

Important Precautions:

• This therapy may not be appropriate for women with certain estrogen-sensitive cancers, unexplained vaginal bleeding, active or prior blood clots, stroke, heart attack, or significant liver disease.
• Risks vary by patient, formulation, route, dose, and duration.

Seek urgent medical attention for chest pain, sudden shortness of breath, coughing blood, one-sided leg swelling, sudden weakness or difficulty speaking, severe new headache, or signs of a serious allergic reaction.

Do not take extra medication to make up for a missed dose. Follow your provider’s instructions, and contact your provider or pharmacist if you are unsure.